Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation
نویسندگان
چکیده
منابع مشابه
Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation
Recent research has shown that fully developed organs can be decellularized, resulting in a complex scaffold and extracellular matrix (ECM) network capable of being populated with other cells. This work has resulted in a growing field in bioengineering focused on the isolation, characterization, and modification of organ derived acellular scaffolds and their potential to sustain and interact wi...
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Initial steps in establishing an optimal strategy for functional bioengineered tissues is generation of three-dimensional constructs containing cells with the appropriate organization and phenotype. To effectively utilize rhesus monkey decellularized kidney scaffolds, these studies evaluated two key parameters: (1) residual scaffold components after decellularization including proteomics analys...
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Allogeneic organ transplantation remains the ultimate solution for end-stage organ failure. Yet, the clinical application is limited by the shortage of donor organs and the need for lifelong immunosuppression, highlighting the importance of developing effective therapeutic strategies. In the field of regenerative medicine, various regenerative technologies have lately been developed using vario...
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For patients with end-stage lung diseases, lung transplantation is the only available therapeutic option. However, the number of suitable donor lungs is insufficient and lung transplants are complicated by significant graft failure and complications of immunosuppressive regimens. An alternative to classic organ replacement is desperately needed. Engineering of bioartificial organs using either ...
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Tissue engineering research, which aims to develop tissue/organ substitutes for treating pathological disorders and organ failures, has made many breakthroughs during the past three decades. The fi eld still faces challenges such as identifying and optimizing scaffolds that must be biodegradable, non-immunogenic, and able to provide structural, mechanical, biological supports/cues for cell adhe...
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ژورنال
عنوان ژورنال: Materials
سال: 2016
ISSN: 1996-1944
DOI: 10.3390/ma9030190